Management of urinary tract infections in adults: An overview

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Dbase IV Applications On Bike Supply System

With the bike inventory system that uses a computer device is expected to assist in inventory and perform everyday tasks better and the preparation of regular reports and data that can generate the information required by the warehouse and the store sales.Application system using DBaseIV program can provide information on bicycle supplies to assist, expedite and facilitate the activities of stock and stock bikes in the warehouse or store inventory and sales so that the risk of error is very small

Evaluation of FRP concrete compression member under repeated load and harsh environment

Strengthening and rehabilitation have been increasingly applied in many structures to improve their capacity and serviceability. Fiber Reinforced Polymer (FRP) materials are universally known for their ability to improve the load capacity of damaged structural elements because of their high linear-elastic behavior. However, enhancing the capacity of structural elements that are exposed to repeated load coupled with harsh environment is an area that requires further investigation. This research focused on experimental analysis of the behavior and response of confined and unconfined concrete compression members (300mm x 150mm) under repeated load while exposed to 1440 cycles of seawater splash zone in United Arab Emirates (UAE). Confining concrete compression members with Carbon Fiber Reinforced Polymer (CFRP) and Glass Fiber Reinforced Polymer (GFRP) sheets have increased the load capacity compared to the control sample at room temperature by 110% and 84%, respectively. Results showed that the average value of compressive strength for the confined concrete exposed to sea water splash zone conditions for CFRP and GFRP specimens has decreased by 33% and 23%, respectively, compared to the confined concrete in the room temperature. However, GFRP specimens showed higher performance in compressive strength under sea water splash zone than those of the CFRP specimens. Different mode of failures such as delamination, de-bonding and combination of such modes were observed and related to various exposure factors and mechanical properties

Gene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study

BACKGROUND: Germ-line mutations in genes such as BRCA1, BRCA2, and ATM can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the incidence of sporadic breast cancer in the general population. Therefore, research has been focused on examining associations between common polymorphisms and breast cancer risk. To date, few associations have been described. This has led to the hypothesis that breast cancer is a complex disease, whereby a constellation of very low penetrance alleles need to be carried to present a risk phenotype. Polymorphisms in the manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPX-1) genes have been proposed as low penetrance alleles, and have not been clearly associated with breast cancer. We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together. METHODS: A case-control study nested within the Nurses' Health Study was performed comparing 1262 women diagnosed with breast cancer to 1533 disease free women. The MnSOD (Val16Ala, rs1799725) and GPX-1 (Pro198Leu, rs1050450) were genotyped via TaqMan assay. Disease risk was evaluated using logistic regression. RESULTS: While neither allele alone shows any change in breast cancer risk, an increase in the risk of breast cancer (OR 1.87, 95% CI 1.09 – 3.19) is observed in individuals who carry both the Ala16Ala genotype of MnSOD and the Leu198Leu genotype of GPX-1. CONCLUSION: Polymorphisms in the GPX-1 and MnSOD genes are associated with an increased risk of breast cancer

Muhammad Saw dan Peletakan Dasar Peradaban Islam

. Sejarah pra-Islam dan pasca datangnya nabi Muhammad di tengah peradaban bangsa Arab tentunya merupakan suatu kondisi yang sangat bipolar. Di satu sisi, peradaban pra-Islam banyak terjadi perilaku buruk seperti permusuhan, perselisihan, ketidakadilan, penindasan bahkan pembunuhan merupakan suatu tradisi dekonstruktif dalam tatanan bangsa Arab. Tentunya, hal ini sangat berbeda ketika Muhammad saw. (keturunan Arab) lahir, terjadi Perubahan tatanan yang sangat signifikan mulai dari konsteks keilmuan, sosial, ekonomi, dan aspek-aspek lainnya. Secara kompeherensif, aspek tersebut di atas direkonstruksi dari mukjizat nabi, yakni Alquran sebagai pedoman dasar dan berupa dari tata cara berperilaku nabi, ucapan dan way of life nabi yang terakumulasi dalam hadits mampu menggeser peradaban yang terbelakang menjadi perabadan yang sangat maju di berbagai lini. Penelitian ini mencoba untuk mengkonstelasikan dan mengkomparasikan peradaban bangsa Arab pra Nabi hingga Nabi dilahirkan dan membawa misi revolusioner dengan munculnya peradaban baru, peradaban Islam

Nondense mammographic area and risk of breast cancer

Introduction The mechanisms underlying the strong association between percentage dense area on a mammogram and the risk of breast cancer are unknown. We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk. Methods We conducted a nested case-control study on prediagnostic mammographic density measurements and risk of breast cancer in the Nurses\u27 Health Study and the Nurses\u27 Health Study II. Premenopausal mammograms were available from 464 cases and 998 controls, and postmenopausal mammograms were available from 960 cases and 1,662 controls. We used a computer-assisted thresholding technique to measure mammographic density, and we used unconditional logistic regression to calculate OR and 95% CI data. Results Higher absolute dense area was associated with a greater risk of breast cancer among premenopausal women (ORtertile 3 vs 1 = 2.01, 95% CI = 1.45 to 2.77) and among postmenopausal women (ORquintile 5 vs 1 = 2.19, 95% CI = 1.65 to 2.89). However, increasing absolute nondense area was associated with a decreased risk of breast cancer among premenopausal women (ORtertile 3 vs 1 = 0.51, 95% CI = 0.36 to 0.72) and among postmenopausal women (ORquintile 5 vs 1 = 0.46, 95% CI = 0.34 to 0.62). These associations changed minimally when we included both absolute dense area and absolute nondense area in the same statistical model. As expected, the percentage dense area was the strongest risk factor for breast cancer in both groups. Conclusions Our results indicate that absolute dense area is independently and positively associated with breast cancer risk, whereas absolute nondense area is independently and inversely associated with breast cancer risk. Since adipose tissue is radiographically nondense, these results suggest that adipose breast tissue may have a protective role in breast carcinogenesis

Texture evolution in selective laser melted maraging stainless steel CX with martensitic transformation

Due to high local cooling rates and non-equilibrium directional solidification conditions, selective laser melting (SLM) processed metals exhibit microstructural and textural features significantly different from the conventionally processed ones. The evolution of crystallographic orientations in a maraging stainless steel (commercially known as stainless steel CX) sample fabricated by the SLM process was studied through experimental and modelling approaches Electron backscattering diffraction analysis showed that the dominant texture components in martensite and austenite phases are || building direction and || building direction, respectively. Texture simulation indicated that the formation of crystallographic orientations in the studied sample is the result of two consecutive phase transformations, from initially solidified delta ferrite phase with dominant cube fiber texture to austenite and austenite to martensite

Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs

Background: Secreted luciferases are highly useful bioluminescent reporters for cell-based assays and drug discovery. A variety of secreted luciferases from marine organisms have been described that harbor an N-terminal signal peptide for release along the classical secretory pathway. Here, we have characterized the secretion of Gaussia luciferase in more detail. / Results: We describe three basic mechanisms by which GLUC can be released from cells: first, classical secretion by virtue of the N-terminal signal peptide; second, internal signal peptide-mediated secretion and third, non-conventional secretion in the absence of an N-terminal signal peptide. Non-conventional release of dNGLUC is not stress-induced, does not require autophagy and can be enhanced by growth factor stimulation. Furthermore, we have identified the golgi-associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1) as a suppressor of release of dNGLUC. / Conclusions: Due to its secretion via multiple secretion pathways GLUC can find multiple applications as a research tool to study classical and non-conventional secretion. As GLUC can also be released from a reporter construct by internal signal peptide-mediated secretion it can be incorporated in a novel bicistronic secretion system

Brain herniation in a patient with apparently normal intracranial pressure: a case report

Introduction Intracranial pressure monitoring is commonly implemented in patients with neurologic injury and at high risk of developing intracranial hypertension, to detect changes in intracranial pressure in a timely manner. This enables early and potentially life-saving treatment of intracranial hypertension. Case presentation An intraparenchymal pressure probe was placed in the hemisphere contralateral to a large basal ganglia hemorrhage in a 75-year-old Caucasian man who was mechanically ventilated and sedated because of depressed consciousness. Intracranial pressures were continuously recorded and never exceeded 17 mmHg. After sedation had been stopped, our patient showed clinical signs of transtentorial brain herniation, despite apparently normal intracranial pressures (less than 10 mmHg). Computed tomography revealed that the size of the intracerebral hematoma had increased together with significant unilateral brain edema and transtentorial herniation. The contralateral hemisphere where the intraparenchymal pressure probe was placed appeared normal. Our patient underwent emergency decompressive craniotomy and was tracheotomized early, but did not completely recover. Conclusions Intraparenchymal pressure probes placed in the hemisphere contralateral to an intracerebral hematoma may dramatically underestimate intracranial pressure despite apparently normal values, even in the case of transtentorial brain herniation